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4.1 Restoration of skin barrier integrity Disruption of the skin barrier, comprising the stratum corneum, lamellar lipids, tight junctions, and cutaneous microbiota, is a central pathophysiological hallmark of AD, as part of the broader mechanisms illustrated in Figure 4

Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC from breastfeeding and because semaglutide injection can be considered for use during lactation, advise patients that breastfeeding is not recommended during treatment with oral semaglutide tablets