iodine and glutathione Redox reaction of glutathione disul fi de; Ellman A Review of High-Dose Iodine

PLoS ONE 7 , e33503 (2012)

Wu, C.-C

Localized injection (near the injury): May provide higher local peptide levels Often used for acute, localized injuries Inject within 23 inches of the injury site Can be combined with systemic injections Common in the first 12 weeks Systemic injection (abdominal): Provides whole-body distribution Suitable for multiple injuries or chronic conditions More convenient for long-term protocols Effective for internal organ healing Standard approach for general support Combined approach: Some protocols use both Example: a localized injection at the injury plus a systemic injection elsewhere May provide both local and systemic effects Requires higher total peptide amounts Storage and Handling Proper storage preserves potency and stability

Additionally, metformin reduces the acetylation of mitochondrial SOD2 by increasing the expression of SIRT3, decreases the production of ROS, and subsequently restores mitochondrial ATP levels to reverse mitochondrial morphological changes, mitigate apoptosis, inflammation, and fibrosis induced by FA/IRI (Zhu et al., 2023)