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ACLY-dependent histone acetylation has also been linked to selective control of key genes involved in glucose usage in adipocytes, including phosphofructokinase (PFK) and glucose transporter 4 (GLUT4) 90

However, AS-IV markedly lowers the upregulated -catenin, TGF-1 and p-Smad3 levels in podocytes and MCs with miR-21 overexpression and promotes the recovery of Smad7 activity