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1528-P: hypothalamic SEL1L-HRD1 ER-associated degradation is indispensable for leptin signaling in diet-induced obesity by degrading misfolded leptin receptor

Cretinism is always associated with significant impairment in mental function, such as hypothyroidism and/or defects in hearing, speech, stance, gait, and growth

Data limitations: No completed human efficacy trial exists for any indication, and the literatures short observation windows mean long-term safety in either animals or humans remains unestablished

Simple intuition Doubling the liquid volume halves the concentration, so the same target amount will need roughly twice the draw volume