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Another study revealed that ketogenic diet intervention reduced social deficits, repetitive behaviors, memory impairments, and inflammatory markers such as TNF-, IL- 1, and IL- 6 in BTBR rats [47]

Key points Parkinson disease (PD) is the fastest growing neurological disorder globally but, currently, no therapeutic intervention can modify disease progression and treatment is still based on levodopa (either alone or in combination with dopamine agonists or monoamine oxidase B or catechol- O -methyltransferase inhibitors) and device-aided therapies

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic