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In the Ehrlich ascites carcinoma mouse model, BV has been found to lower MMP-2 and MMP-9, as well as VEGF, TNF-, and nitric oxide (NO) levels, hence decreasing tumor growth and preventing angiogenesis (Lee et al., 2017)

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The absence of marketing authorisation also means that no approved UK product information defines a human dose, indication, contraindication, adverse-effect profile or monitoring programme

A provider-directed plan often starts with an introductory concentration, such as 1% to 2%, once daily to assess tolerance