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Like other biologicals targeting IGF-IR simultaneously under development at several other pharmaceutical companies, the efficacy of teprotumumab was found inadequate for sustaining its development program by Roche (107, 109111, 126)

Fluorescence or X-ray cholangiography in elective laparoscopic cholecystectomy: a randomized clinical trial

While it was previously believed that carriers of germline pathogenic PMS2 variants represented a small minority of LS patients, recent studies have challenged this assumption

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