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To suppress disulfidptosis, two protein repair systems, the Trx system and the glutaredoxin (Grx) system, balance the conversion of thiol groups and disulfide bonds

Figure 2 2.1 Modulation of innate immune cell populations by bile acids 2.1.1 Macrophages: polarization, phagocytosis, and cytokine production Macrophages are key targets of bile acids (BAs) in the TIME, given their immune plasticity and roles in inflammation and tumor progression ( Macrophage BA responses are mediated by receptors such as farnesoid X receptor (FXR), Takeda G protein-coupled receptor 5 (TGR5), vitamin D receptor (VDR), liver X receptor alpha (LXR), and peroxisome proliferator-activated receptor gamma (PPAR) ( However, BA effects are context-dependent

Minutolo A, Petrone V, Fanelli M et al (2023) Thymosin alpha 1 restores the immune homeostasis in lymphocytes during Post-Acute sequelae of SARS-CoV-2 infection

Different research works have been carried out, such as dietary intervention and high fiber to support the growth of healthy microbes