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Grade 4 liver injury: Molecular targeted therapy should be permanently discontinued, and aggressive anti-inflammatory, hepatoprotective, and supportive therapy should be administered immediately

found that 600mg/kg oral tenofovir was able to induce the Fanconi syndrome, acute tubular nephrotoxicity and renal dysfunction and these abnormalities were effectively countered by melatonin pretreatment.124 Biochemical data revealed that tenofovir induce the urinary potassium, phosphate, bicarbonates, urea and serum uric acid which were restored, except phosphate, with melatonin (20mg/kg) pretreatment

The stationary phase mostly consists of agarose or synthetic polymers and is packed into a column in the form of beads

We did not perform genetic testing, and the diagnosis was made clinically