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Pooled results demonstrated a significant reduction in weight following LC supplementation, but the subgroups analysis revealed no significant effect of LC on body weight in subjects with body mass index (BMI) below 25 kg/m 2

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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66