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Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Additional representative therapeutic agents include radioisotopes, chemotherapeutic agents, immunomodulatory agents, anti -angiogenic agents, anti-proliferative agents, pro-apoptotic agents, and cytolytic enzymes e.g., RNAses)

89 As BH 4 is very susceptible to oxidation, ONOO , resulting from the reaction of NO with superoxide anion, may oxidize BH 4 to the BH 3 radical and, thus, the resulting decrease in endothelial BH 4 can induce eNOS uncoupling

KoutlasNTEluriSRusinSPerjarIHollyfieldJWoosleyJTet alImpact of smoking, alcohol consumption, and NSAID use on risk for and phenotypes of eosinophilic esophagitis