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Chi-square tests were used to examine the association between treatment and the 20% and 50% reductions in HAM-D outcomes

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Standard Dose: 5 mg (12 clicks) once daily (1 click 0.417 mg/417 mcg) Alternative / Higher Dose (if tolerated): Up to 10 mg (24 clicks) daily Frequency: Once daily Timing: Morning, on an empty stomach (wait 30-60 minutes before eating) to optimize metabolic effects Cycle: 20 consecutive days on, followed by 2 weeks off (repeat as needed) Administration Instructions Wash hands and prepare a clean surface