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FDA-approved alternatives like semaglutide (10-15% loss), tirzepatide (15-22% loss), and CagriSema (15-25% loss) offer comparable or superior results with proven long-term safety profiles, cardiovascular benefits rather than risks, and legal medical oversight

Practical note on titration: tirzepatide titration schedules described in trial and community sources typically step up from 2.5 mg 5 mg 7.5 mg 10 mg 15 mg every 4 weeks