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Further exploration of the lactylation mechanism within the TME, the discovery of novel regulatory targets, the development of therapeutics targeting lactylation-related enzymes and proteins, the integration of these approaches with conventional treatment modalities, and the enhancement of immunotherapeutic strategies are promising avenues to improve cancer treatment outcomes, offering new hope and expanding the array of treatment options for patients with cancer

Findings from the ONTARGET/TRANSCEND trials revealed that the use of angiotensin-converting enzyme (ACE) inhibitors or ARBs contributed to the reduction of albuminuria and a decrease in cognitive decline among individuals with CKD (140)

Rocha EM, Keeney MT, Di Maio R, De Miranda BR, Greenamyre JT