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SKU: 90494197893
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Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, et al

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2-ME2 suppresses the mitochondrial abnormalities Mitochondrial dysfunction is a key feature of PAH and is characterized by a metabolic shift from glucose oxidation to uncoupled aerobic glycolysis, known as the Warburg metabolic transition [89]

This may stem from the fact that SLC25A45 KO cells are obligated to generate carnitine from other sources (for example, from -BB), as the regular murine diet used in this study contains undetectable levels of carnitine ( Fig