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Although these models were not originally developed to study ECD, they hold significant potential for such applications

Recent research has demonstrated that males with low-birth-weight exhibit decreased expression of GLUT4, protein kinase C, and phosphoinositide 3-kinase p85 and p110 subunits in their muscles

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Thus these various types of heterogeneity may be responsible for the discrepancies in the results of COVID-19 microbiome studies published and makes it impossible to meaningfully compare on a one-to-one basis, and makes meta-analysis more difficult, as combining data across studies without considering heterogeneity may mask real signals [48,65]