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Symptoms of vitamin B12 deficiency include: fatigue, irritability, anxiety, low energy, depression, forgetfulness, constipation, new food sensitivities, hot and cold flashes, sore muscles, pale skin, numbness, tingling, and dermatitis

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Notably, outliers detected both at PRE-START and at the time of DARA treatment failure pointed to biologically distinct, potentially genetically driven MM subgroups with divergent therapeutic responses ( Figure 5 ) confirmed consistent detection of ADO and INO but revealed divergent dynamics, highlighting the need for personalized metabolic monitoring