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x Heart Disease: A 2017 Canadian meta-analysis reported increases in weight and waist circumference, and higher incidence of obesity, hypertension, metabolic syndrome, type 2 diabetes and cardiovascular events. A 2016 paper found significantly increased weight gain, adiposity, incidence of obesity, cardiometabolic risk, and even total mortality among individuals with chronic, daily exposure to low-calorie sweeteners and these results are troubling. xi Neurological Issues : Consuming diet sodas leads to a three-fold increase in risk for stroke and dementia

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ALT or AST substrate (12.5 l) was added to serum or standard (2.5 l) and incubated at 37 C for 1 h

From this research it seems that the best explanations may be through the potential reset of a disrupted methionine-folate cycle and aiding in the removal of toxic metals and chemicals from the brain