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Glossary AE Adverse event APC Antigen-presenting cells BCPNN Bayesian confidence propagation neural network CD Cluster of differentiation CI Confidence interval CRS Cytokine release syndrome dICI Dual immune checkpoint inhibitor/Ipilimumab+Nivolumab or Tremelimumab+Durvalumab DIG Dual immunotherapy group/Ipilimumab+Nivolumab and Tremelimumab+Durvalumab FAERS The US Food and Drug Administration Adverse Event Reporting System IC 025 95% CI lower limit of information component ICI Immune checkpoint inhibitor irAE Immune-related adverse event MedDRA Medical Dictionary for Regulatory Activities NSCLC Non-small cell lung cancer PS Primary suspect PT Preferred term Q1 Lower quartile Q3 Upper quartile ROR Reporting odds ratio ROR 025 95% CI lower limit of ROR SD Standard deviation sICI Single immune checkpoint inhibitor SOC System organ class Treg Regulatory T cell

PEG-MGF is a PEGylated form of mechano growth factor (MGF), the IGF-1Ec splice variant produced locally in muscle in response to mechanical loading or injury