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It holds the potential to elucidate the impact of cellular growth conditions such as heat-shock, starvation, or UV damage on the 20S substratome, while also uncovering differences between diverse cell types

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In addition to its role in mediating enzyme activity, Mn also serves as a cofactor in immunological pathways, such as T-cell receptor signaling 129 , immune cell adhesion 130 , and the cGAS/STING pathway, thus playing a key role in the sensitization of tumor immunity and protection against viral infection 131,132