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Any intervention that might improve muscle preservation has proportionally greater value in this population, even if the absolute effect is modest

There are no documented interactions between TMA and any known organ or physiological function [4]

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Interestingly, after a week-long suppression of the gut microbiota with oral broad-spectrum antibiotics cocktail, a rechallenge with oral d 9 -BB showed complete suppression of d 9 -TMAO formation in subjects, confirming gut microbiotadependent conversion of BB into TMAO (Figure 2A, open circles)