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Increased participation in the Shared Savings Program will extend ACO care coordination and quality improvement to segments of the beneficiary population that potentially have more to benefit from care management

Additional mechanistic references address NAD-associated metabolic networks, energy balancerelated pathway models, and coordinated methyl donor utilization examined under experimental research conditions

No peer-reviewed study has tested any pairwise combination of the three

Generally, these new strategies should be directed towards diseases with significant unmet clinical needs, including cases that have relapsed or are resistant to current treatments, as well as rare (orphan) diseases