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Such level-specific alterations in E/I balance along the cortico-spinal axis may represent compensatory or maladaptive responses that ultimately converge to impair motor circuit integrity and contribute to disease progression

Mutations in the LMNA gene can cause a group of genetically and clinically heterogeneous disorders known as laminopathies

Tauopathy is characteristic of the major neurodegenerative disease, Alzheimers disease (AD) [349], where tau protein is aberrantly hyperphosphorylated and forms bundles of filaments [350]

Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics