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LIAR hypothesis revisited: perspectives on the functional significance of mucosal eosinophils In 2010, Lee 53 and colleagues published a provocative hypothesis challenging the dogmatic view of eosinophils as solely evolving for the purpose of functioning as innate immune end-stage effector cells in type II responses

A global view of hepatocellular carcinoma: Trends, risk, prevention and management

83 In the future, combining microbiome sequencing and immune profiling is expected to enable personalized microbial interventions, such as transplanting beneficial flora to sensitize HCC patients ineffective to ICI therapy, or customizing probiotic formulas regulating immune balance for autoimmune liver disease patients, truly realizing the immune therapy paradigm shift from targeting the liver to targeting the intestinal niche. In HCC patients, the treatment regimen of nivolumab combined with oral vancomycin and tadalafil led to changes in the gut microbiome, reduced secondary bile acids, and significant changes in peripheral blood monocyte subsets

Can we start there