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Alterations in GLS activity have been associated with various pathologies like cancer, hyperammonemia, and neurological disorders, including behavior abnormalities, as well as cognitive and motor deficits ( Glutamine as a conditionally essential immunonutrient Under normal physiological conditions, glutamine remains non-essential as the human body can endogenously produce from 40 to 80 g/L glutamine ( Glutamine as one of the drivers of immunosuppression During pathological conditions such as cancer and infections, the immune cells driving immunosuppression include myeloid-derived suppressor cells (MDSCs), regulatory T-cells (Tregs), and M2 macrophages ( N -acetylglucosamine pathway and glutamine-derived -KG ( Glutamine metabolism in infectious diseases (bacterial, viral, and fungal) The speculation that glutamine plays a substantial role in infectious diseases dates back to 1975 when depletion of skeletal muscle Glutamine pool was detected under stress conditions like surgery, trauma, and inflammatory conditions

N-Acetylcysteine (NAC) is the synthetic precursor of intracellular GSH and is used to increase GPX enzyme activity (Fig

doi: 10.1242/dmm.049082 84 LebouvierT.NeunlistM.des VarannesS

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