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Prominent features include epithelial barrier dysfunction, delayed or accelerated gastrointestinal transit due to abnormal function of smooth muscles, dysfunctional enteric nervous system and/or immunity, gut microbial dysbiosis, bile acid malabsorption, and alterations in the gut-brain axis (812)

These effects can happen more often with larger peptides, hydrophobic peptides, basic peptides, or solutions prepared at very high concentration

Personal fit: Your ideal split depends on your body, your goals, and where your chest needs the most work right now

These agents, though not yet part of mainstream treatment guidelines, offer promising adjunctive strategies for individuals in early recovery and beyond