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Since Vs downregulated the expression of Nrf2 dependent antioxidant systems in U1, we performed RTqPCR analysis of a selected set of Nrf2dependent genes (GPX1, GPX4, GSR, and SRXN1) in CD4 + T cells at 21 days posttreatment with ARVs alone or Vs + ARVs

Role of HDACs in epilepsy Although the pathogenesis of epilepsy has not been fully established, excitotoxicity, oxidative stress and neuroinflammation are regarded as the triads of epileptogenesis, a process during which triggers of brain insults such as status epilepticus by chemoconvulsants, infection or cerebrovascular disease include and the brain undergoes a cascade of morphological and functional changes prior to the onset of spontaneous recurrent seizures in chronic epilepsy [98], and epilepsy-associated neurodegeneration

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