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For this reason, antihistamines are mainly used in acute or severe cases, or when it is not possible to follow a low-histamine diet [8], or when the administration of drugs that may release histamine is unavoidable [93]

Application of this assay to analyze plasma from patients with known oxidative stress (sickle cell disease and sepsis) and from a patient with sickle cell disease treated with the antioxidant N-acetylcysteine suggests that cysteine disulfides, in particular protein-bound cysteine, serve as sensitive plasma biomarkers for the extent of oxidative stress and effectiveness of antioxidant treatment

Importantly, we found HLA-B, HLA-E, and PSMB10 all related to antigen presentation to be enriched among down-regulated genes in tumours with high LEF-1 expression ( Figure 8 , Table 1 ) suggesting an adverse impact of Wnt/-catenin pathway on tumour recognition by immune cells