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Although metabolomics has improved the understanding of the pathogenesis of RA, some studies have reported inconsistent results (6466)

The transcription factor NF-B is an important regulator of immune and inflammatory responses, and NF-B p65-mediated increased trans-activation plays a key role in the pathogenesis of chronic inflammatory diseases (210)

When evaluating the quality of the 18 articles 2 , 6 , 11 - 26 selected through the Jadad Scale, their scores ranged between 2 and 5, with a median score of 5 (Table 1)