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In fact, protein crystallography was started by the pioneering work of John Desmond Bernal (19011971) and Dorothy Crowfoot Hodgkin (19101994), who reported the first X-ray photographs of crystalline pepsin in 1934 (Kendrew et al., 1958)

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On the other hand, excessive intake of certain nutrients, such as iron and copper, can increase oxidative stress and disrupt metal homeostasis, leading to tissue damage and impaired detoxification