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Angiogenesis plays a crucial role in the process of tumour genesis, because solid tumour need a blood supply if they are to grow beyond a few millimeters in size

Malabsorption (insufficient absorption of vitamin B 12 in the intestine) due to, insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and is required for the absorption of vitamin B 12 ), Diseases in the end section of the ileum (part of the small intestine), e.g.B