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in healthy cells, this ratio is approximately 100 : 1, but it can decrease to 10 : 1 or 1 : 1 under oxidative stress [161, 162]

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In terms of GABA concentration, the brain contains a high concentration with an average value of 23 mmol/g wet weight (2030 mmol/g protein) and a regional distribution of 1030 mmol/g protein, whereas most peripheral tissues have low GABA content, which is approximately 1% of that in the brain 21