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Physical characterization was performed via particle analyzer/zetasizer, electron microscopy [SEM/TEM] analysis and protein identification, quantification was performed by Western blot analysis for known EV markers of lysed EVs

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Lifestyle interventions for the prevention of Parkinson disease

Table 1, although first-generation antifibrotic drugs, such as pirfenidone and nintedanibapproved over a decade agohave demonstrated efficacy in slowing IPF progression and improving survival rates in clinical trials, their benefits are constrained by significant side effects (e.g., nausea, diarrhea, and photosensitivity) that compromise long-term tolerability (King et al., 2011