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[DOI] [Google Scholar] 251.Vinson J.A., Kharrat H.A., Andreoli L

According to the positive pleiotropy hypothesis, it is the endometrium and its controlling mechanisms that determine the degree of trophoblast invasion and dictate the type of placentation in eutherian mammals ( Placental development and pregnancy-related diseases The placenta plays crucial protective roles for the fetus, but its structure and function are also associated with pregnancy complications such as IR, preeclampsia, and eclampsia (166168)

Afterwards, next-generation sequencing was developed as a tool for detecting methylation in short DNA strands (short-read sequencing) [6, 16, 24]