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Sorafenib is currently used as the first-line drug for the treatment of advanced HCC, and studies have shown that it could induce ferroptosis of HCC cells and thereby inhibit their proliferation ( The available targets for ferroptosis in liver diseases The present therapeutic strategies for ferroptosis mainly include genes, RNAs, proteins, small-molecule compounds and nanomaterials

464 Systemic and pulmonary hypertension are the main clinical causes of heart enlargement, cardiac fibrosis, and eventually heart failure

Always watch for regulatory updates, especially for Category 1 and 2 status on FDA lists

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