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Thus, GSTP1 is a lactatebinding protein, the function of which is probably modulated in response to lactic acid levels that constitute, at least in part, a tumor metabolic micro-environment

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Although structural studies have successfully mapped the key regulatory interfaces, it remains unknown whether botanical compounds can selectively disrupt the inhibitory Beclin1Bcl-2 interaction without simultaneously affecting the functionally essential Beclin1Vps34 association

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