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The CHY was discovered to be anchored to the active 4DES binding site by residues ALA109 and SER117

A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

This process is directly regulated by multiple key oncogenic signaling pathways [138]

While previous studies have demonstrated that oxidative stress plays a critical role in the AhR-dependent toxic response, the effect of PAHs on GSH biosynthesis has not been extensively investigated