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Introduction High-quality clinical evidence is essential for guiding therapeutic decisions, informing policy, and improving patient outcomes

The escalation phases are only required during the first cycle

& Bjorntorp, P

IWR-1, a tankyrase inhibitor, attenuates Wnt/beta-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft