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The structure of rapamycin was solved by X-ray crystallography in 1978, 15 allowing it to be classified as a macrolide

This observation is important because the conventional assumption, based on rodents, has been that esterified forms of vitamin E such as a-tocopheryl acetate, a-tocopheryl nicotinate, and a-TS can be absorbed from the intestinal tract only after they are hydrolyzed to a-tocopherol

Hence, the aim of this review is to depict the current molecular and pharmacological knowledge on glutathione, focusing on the available studies related to its therapeutic activity in NAFLD