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Research published in journals including the Journal of Neurochemistry and Brain Research has examined the molecular mechanisms underlying these effects with Semax-induced upregulation of BDNF, NGF, and TrkB identified as key mediators of the observed neuroprotection, alongside modulation of the inflammatory cytokine cascade in peri-infarct brain tissue

The myelin sheath acts as an insulating shield, facilitating the rapid propagation of action potentials as well as providing structural and trophic support to neurons (Bradl and Lassmann, 2010)