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These HMOX2 mutants (HW/GW, G163H and C265A) were localized to the ER and were ubiquitinated by MITOL, supporting a role for MITOL-mediated ubiquitination at K68 in facilitating HMOX2-dependent haem degradation (Extended Data Fig

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10 Potentiators enhance CFTR function via channel gating augmentation, promoting mucus transport, and decreasing mucus adhesion to epithelial surfaces