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Because Arg67 is the ligand that directly interacts with MDSA, the R67A mutant demonstrated activity that was notably less inhibited by MDSA, with an IC 50 value of 185 M, which was over 300-fold that of the WT (Table 1)

Since LMNA (E358K) which showed a slightly lower muscle endurance trend, we tested AB(WT), LMNA (WT), LMNA (L35P), LMNA (R453W), and LMNA (A539V) fish with these five selected drugs (Fig

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Both the AE and AE+N-CUR groups demonstrated a pronounced downregulation of TGF-1 in comparison to tumor control subjects, with the combined treatment exhibiting the most substantial effect