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SorrentiSBaldiniEPironiDLauroAD'OraziVTartagliaFet al

It might be normal body changes, pigmentation due to sun damage, certain medicines, irritation, low vitamins like B12 or folate, smoking, or other health issues 4

Interestingly, in HCC, exopolysaccharides derived from Enterobacter faecium [171] enhanced ferroptotic cell death by promoting IFN-CD8 T cell-mediated downregulation of SLC7A11, suggesting a potential therapeutic strategy by promoting microbiota-liver ferroptosis [171]