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These tools contrast with strategies that aim to reprogram hepatic rhythmicity, such as compounds that act on the molecular clock (e.g., ROR agonists and REV-ERB inhibitors)

Melatonin-mediated BMI1 regulation and the latter's role in inducing mitophagy to curb oxidative stress could set a path for establishing melatonin as a therapeutic candidate for Parkinsons Disease

TABLE 2 Molecular regulation of circadian clock components by deubiquitinating enzymes

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