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Over 84% of all e-cigarette advertising expenditures were focused on the retail environment , with the largest categories for expenditure being price discounts, promotional allowances, and point-of-sale advertising

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Smoking is a significant risk factor for bladder cancer, responsible for approximately 50% of cases and increasing the risk by two to three times compared to non-smokers, with a dose-dependent relationship between smoking intensity and tumor aggressiveness 5