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Impact on Gut Microbiome The gut microbiome consists of trillions of beneficial bacteria that aid digestion and support immune function

Cannabis use exhibits a similarly paradoxical profile: acutely, some individuals report anxiolytic or mood-elevating effects from cannabis, yet sustained use is associated with worsened symptom severity, poorer treatment adherence and poorer functional outcomes 39

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Although the previous studies have reported the intermediate degradation products and metabolic mechanisms of nicotine in the different strains, the comprehensive pathways, metabolic mechanisms and associated genes involved in the degradation of TSNA, -carotenes, starch, protein and other compounds in tobacco microorganisms remain to be elucidated