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The technique is especially appropriate for testing the whole taste sensory chains integrity including ionotropic transduction mechanisms, but excluding metabotropic transduction mechanisms because sweet bitter or umami taste transduction mechanisms rely on second messenger systems and are not activated by EGM stimulation (ionic stimuli) [43]

The use tends to be long-term and remains mainly linked to tobacco: more than half (59 %) of adult vapers have been using electronic cigarettes for two years or more, nearly two-thirds (65 %) of adult vapers continue to consume tobacco, and almost all (98 %) are smokers or former smokers

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