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Caius Bourgeois, a 17-year-old from Baltimore County, began smoking blunt wraps at the age of 14

Tobacco use also leaves smokers more susceptible to infections and gum disease

It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]