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These symptoms primarily include dyspepsia, constipation, fatigue, polyuria, and depression, which are collectively referred to as kidneyyang deficiency syndrome. In analyzing the symptoms related to specific genes in LF, we identified a broad spectrum of clinical manifestations affecting various body systems, including acute pain, dizziness, headache, fever symptoms, skin itching, chronic fatigue, and muscle weakness, commonly classified under kidneyyin deficiency syndrome. Discussion Study summary Constructing associations among medications, diseases, and symptoms is crucial for understanding a range of severe symptoms caused by osteoporosis, such as pain, muscle weakness, and frailty