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Topical forms work well for localized skin applications but have limited penetration depth

Luo R, Su L-Y, Li G, Yang J, Liu Q, Yang L-X, et al

doi: 10.1186/1478-811x-9-13 106 MagneTMHelal-NetoECorreaLBRebelo AlencarLMGemini PiperniSIramSHet al

In addition, loss of podocytes, either due to apoptosis and/or podocyte detachment from the glomerular basement membrane, was shown to be an early event in the development of diabetic nephropathy in humans and various animal models of diabetic nephropathy [196,197,198]